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THERE'S A FLARE
BEHIND EVERY FLARE-UP

THERE'S
A FLARE
BEHIND
EVERY
FLARE-UP

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THE FLARES YOU CAN'T SEE

Not all the effects of psoriasis are visible on the skin.1

The psychological burden may persist even with skin clearance. And that means, even when their skin is clear, psoriasis may still impact their mental well-being.1,2

Living with psoriasis means always having to think twice. It's an ever-present voice in the back of the mind that wonders:

"Will this be a trigger?"

"What if I have a flare-up?"

"Is my skin going to be clear next week?"

Behind every psoriasis flare-up, there's an emotional flare and a call for help.

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BURNED OUT: THE TRUE IMPACT OF PSORIASIS

Psoriasis can have a profound impact on patients' quality of life.2

Living with itchy, painful, and unsightly plaques can cause significant social, emotional, and physical distress. Feelings of shame and embarrassment are common in people with psoriasis, and they're at major risk of depression.1,2

In fact, a recent study found that people with psoriasis suffer from a range of other problems3:

Social challenges head

94%

Deal with
social
challenges

Work difficulties

68%

Struggle with
professional
difficulties

Physical limitations

38%

Have
physical
limitations

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ANSWERING THE CALL FOR HELP: HOW DERMAVANT IS RETHINKING THE SCIENCE BEHIND PSORIASIS

Psoriasis is a chronic, immune-mediated skin disorder where several mechanisms in the skin become dysregulated, leading to chronic inflammation.4,5

Shield blocking cell

IMMUNE CELL RESPONSE

Th17 immune cells are elevated, leading to the overproduction of proinflammatory cytokines such as IL-17A and IL-17F.6,7

Skin barrier dysfunction

SKIN BARRIER DYSFUNCTION

Proinflammatory cytokines promote excessive growth of keratinocytes and reduce production of proteins that are essential for skin repair.5,8

Oxidative stress

OXIDATIVE STRESS

Sustained inflammation causes excessive reactive oxygen species production, exacerbating oxidative damage.9

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GETTING UNDER THE SKIN OF PSORIASIS

Learn more about the mechanism of disease in psoriasis and the role of AhR signaling.

Skin City: "Mechanism of disease in psoriasis"

EPISODE 1:
SKIN CITY IS IN DANGER

Jump into a world where psoriasis has taken over and our hero, AhR, struggles to maintain order.

Episode 2: They're Everywhere

EPISODE 2:
THEY'RE EVERYWHERE

Cytokines have overthrown major parts of Skin City. AhR tries to find a way to stop them.

Episode 3: A City of Change

EPISODE 3:
A CITY OF CHANGE

Things have taken a turn in Skin City, and AhR might just need your help.

Mechanism of disease in psoriasis

MECHANISM OF ACTION

Take a deep dive into the science behind psoriasis and see how our discoveries offer hope of a new approach to this chronic condition.

THE ROLE OF ARYL HYDROCARBON RECEPTOR (AhR)

AhR is a ligand-dependent transcription factor that regulates diverse, multifunctional pathways. It plays an important balancing role in skin homeostasis.10

AhR signaling could help restore order and balance to the dysregulated mechanisms in psoriasis.

  • AhR suppresses Th17 cell growth and production of key cytokines, such as IL-17 and IL-2211
  • AhR upregulates the production of skin barrier proteins to restore skin barrier function12
  • AhR induces the Nrf2 transcription factor pathway to increase antioxidant activity13
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THE MISSION BRIEFING: EXPERT PERSPECTIVES IN PSORIASIS

THE MISSION BRIEFING:
EXPERT PERSPECTIVES
IN PSORIASIS

In this podcast series, Linda Stein Gold, MD, talks to Jonathan Weiss, MD, and Keri Holyoak, PA, MPH, about unmet needs and the science behind psoriasis.

In this podcast series, Linda Stein Gold, MD, talks to Jonathan Weiss, MD, and Keri Holyoak, PA, MPH, about unmet needs and the science behind psoriasis.

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8 MILLION PEOPLE
IN THE US HAVE PSORIASIS14


8 MILLION PEOPLE
IN THE US HAVE PSORIASIS14

It's time to change our approach to the skin condition and answer their calls for help.

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STAY IN THE LOOP

Join us and other dedicated healthcare professionals to get updates on how you can help change the way we see plaque psoriasis. Stay on top of it — you can count on new information and more than meets the surface.

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YOU'RE ON YOUR WAY

Thank you for joining us on our journey. You'll be hearing from us soon.

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References:

1. Schmid-Ott G, Böhm D, Gissendanner SS. Patient considerations in the management of mental stress in psoriasis. Patient Intell. 2012;4:41-50. 2. Armstrong AW, Schupp C, Wu J, Bebo B. Quality of life and work productivity impairment among psoriasis patients: findings from the National Psoriasis Foundation survey data 2003–2011. PLOS One. 2012;7(12):e52935. 3. Pariser D, Schenkel B, Carter C, Farahi K, Brown TM, Ellis CN; Psoriasis Patient Interview Study Group. A multicenter, non-interventional study to evaluate patient-reported experiences of living with psoriasis. J Dermatolog Treat. 2016;27(1):19-26. doi: 10.3109/09546634.2015.1044492. 4. Psomadakis CE, Han G. New and emerging topical therapies for psoriasis and atopic dermatitis. J Clin Aesthet Dermatol. 2019;12(12):28-34. 5. Rendon A, Schäkel K. Psoriasis pathogenesis and treatment. Int J Mol Sci. 2019;20:1475. 6. Greb JE, Goldminz AM, Elder JT, et al. Psoriasis. Nat Rev Dis Prim. 2016;2:1-17. 7. Brembilla NC, Senra L, Boehncke W-H. The IL-17 family of cytokines in psoriasis: IL-17A and beyond. Front Immunol. 2018;9(1682):1-13. 8. Kim BE, Howell MD, Guttman E, et al. TNF-α downregulates filaggrin and loricrin through c-Jun N-terminal kinase: role for TNF-α antagonists to improve skin barrier. J Investig Dermatol. 2011;131:1272-1279. 9. Cannavò SP, Riso G, Casciaro M, Di Salvo E, Gangemi S. Oxidative stress involvement in psoriasis: a systematic review. Free Rad Res. 2019;53(8):829-840. 10. Bissonnette R, Stein Gold L, Rubenstein DS, Tallman AM, Armstrong AW. Tapinarof in the treatment of psoriasis: a review of the unique mechanism of action of a novel therapeutic aryl hydrocarbon receptor–modulating agent. J Am Acad Dermatol. 2021;84:1059-1067. 11. McAleer JP, Fan J, Roar B, Primerano DA, Denvir J. Cytokine regulation in human CD4 T cells by the aryl hydrocarbon receptor and Gq-coupled receptors. Sci Rep. 2018;8:10954. doi:10.1038/s41598-018-29262-4. 12. Sutter CH, Bodreddigari S, Campion C, Wible RS, Sutter TR. 2,3,7,8-tetrachlorodibenzo-p-dioxin increases the expression of genes in the human epidermal differentiation complex and accelerates epidermal barrier formation. Toxicol Sci. 2011;124(1):128-137. 13. Dietrich C. Antioxidant functions of the aryl hydrocarbon receptor. Stem Cells Int. 2016;2016:7943495. doi:10.1155/ 2016/‌7943495. 14. National Psoriasis Foundation. About psoriasis. https://www.psoriasis.org/about-psoriasis/. Accessed November 2020.

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