THERE'S A FLARE
BEHIND EVERY FLARE-UP
THERE'S
A FLARE
BEHIND
EVERY
FLARE-UP
THE FLARES YOU CAN'T SEE
Not all the effects of psoriasis are visible on the skin.1
The psychological burden may persist even with skin clearance. And that means, even when their skin is clear, psoriasis may still impact their mental well-being.1,2
Living with psoriasis means always having to think twice. It's an ever-present voice in the back of the mind that wonders:
"Will this be a trigger?"
"What if I have a flare-up?"
"Is my skin going to be clear next week?"
Behind every psoriasis flare-up, there's an emotional flare and a call for help.
BURNED OUT: THE TRUE IMPACT OF PSORIASIS
Psoriasis can have a profound impact on patients' quality of life.2
Living with itchy, painful, and unsightly plaques can cause significant social, emotional, and physical distress. Feelings of shame and embarrassment are common in people with psoriasis, and they're at major risk of depression.1,2
In fact, a recent study found that people with psoriasis suffer from a range of other problems3:
94%
Deal with
social
challenges
68%
Struggle with
professional
difficulties
38%
Have
physical
limitations
ANSWERING THE CALL FOR HELP: HOW DERMAVANT IS RETHINKING THE SCIENCE BEHIND PSORIASIS
Psoriasis is a chronic, immune-mediated skin disorder where several mechanisms in the skin become dysregulated, leading to chronic inflammation.4,5
IMMUNE CELL RESPONSE
Th17 immune cells are elevated, leading to the overproduction of proinflammatory cytokines such as IL-17A and IL-17F.6,7
SKIN BARRIER DYSFUNCTION
Proinflammatory cytokines promote excessive growth of keratinocytes and reduce production of proteins that are essential for skin repair.5,8
OXIDATIVE STRESS
Sustained inflammation causes excessive reactive oxygen species production, exacerbating oxidative damage.9
GETTING UNDER THE SKIN OF PSORIASIS
Learn more about the mechanism of disease in psoriasis and the role of AhR signaling.
EPISODE 1:
SKIN CITY IS IN DANGER
Jump into a world where psoriasis has taken over and our hero, AhR, struggles to maintain order.
EPISODE 2:
THEY'RE EVERYWHERE
Cytokines have overthrown major parts of Skin City. AhR tries to find a way to stop them.
EPISODE 3:
A CITY OF CHANGE
Things have taken a turn in Skin City, and AhR might just need your help.
MECHANISM OF ACTION
Take a deep dive into the science behind psoriasis and see how our discoveries offer hope of a new approach to this chronic condition.
THE ROLE OF ARYL HYDROCARBON RECEPTOR (AhR)
AhR is a ligand-dependent transcription factor that regulates diverse, multifunctional pathways. It plays an important balancing role in skin homeostasis.10
AhR signaling could help restore order and balance to the dysregulated mechanisms in psoriasis.
THE MISSION BRIEFING: EXPERT PERSPECTIVES IN PSORIASIS
THE MISSION BRIEFING:
EXPERT PERSPECTIVES
IN PSORIASIS
In this podcast series, Linda Stein Gold, MD, talks to Jonathan Weiss, MD, and Keri Holyoak, PA, MPH, about unmet needs and the science behind psoriasis.
In this podcast series, Linda Stein Gold, MD, talks to Jonathan Weiss, MD, and Keri Holyoak, PA, MPH, about unmet needs and the science behind psoriasis.
8 MILLION PEOPLE
IN THE US HAVE PSORIASIS14
8 MILLION PEOPLE
IN THE US HAVE PSORIASIS14
It's time to change our approach to the skin condition and answer their calls for help.
References:
1. Schmid-Ott G, Böhm D, Gissendanner SS. Patient considerations in the management of mental stress in psoriasis. Patient Intell. 2012;4:41-50. 2. Armstrong AW, Schupp C, Wu J, Bebo B. Quality of life and work productivity impairment among psoriasis patients: findings from the National Psoriasis Foundation survey data 2003–2011. PLOS One. 2012;7(12):e52935. 3. Pariser D, Schenkel B, Carter C, Farahi K, Brown TM, Ellis CN; Psoriasis Patient Interview Study Group. A multicenter, non-interventional study to evaluate patient-reported experiences of living with psoriasis. J Dermatolog Treat. 2016;27(1):19-26. doi: 10.3109/09546634.2015.1044492. 4. Psomadakis CE, Han G. New and emerging topical therapies for psoriasis and atopic dermatitis. J Clin Aesthet Dermatol. 2019;12(12):28-34. 5. Rendon A, Schäkel K. Psoriasis pathogenesis and treatment. Int J Mol Sci. 2019;20:1475. 6. Greb JE, Goldminz AM, Elder JT, et al. Psoriasis. Nat Rev Dis Prim. 2016;2:1-17. 7. Brembilla NC, Senra L, Boehncke W-H. The IL-17 family of cytokines in psoriasis: IL-17A and beyond. Front Immunol. 2018;9(1682):1-13. 8. Kim BE, Howell MD, Guttman E, et al. TNF-α downregulates filaggrin and loricrin through c-Jun N-terminal kinase: role for TNF-α antagonists to improve skin barrier. J Investig Dermatol. 2011;131:1272-1279. 9. Cannavò SP, Riso G, Casciaro M, Di Salvo E, Gangemi S. Oxidative stress involvement in psoriasis: a systematic review. Free Rad Res. 2019;53(8):829-840. 10. Bissonnette R, Stein Gold L, Rubenstein DS, Tallman AM, Armstrong AW. Tapinarof in the treatment of psoriasis: a review of the unique mechanism of action of a novel therapeutic aryl hydrocarbon receptor–modulating agent. J Am Acad Dermatol. 2021;84:1059-1067. 11. McAleer JP, Fan J, Roar B, Primerano DA, Denvir J. Cytokine regulation in human CD4 T cells by the aryl hydrocarbon receptor and Gq-coupled receptors. Sci Rep. 2018;8:10954. doi:10.1038/s41598-018-29262-4. 12. Sutter CH, Bodreddigari S, Campion C, Wible RS, Sutter TR. 2,3,7,8-tetrachlorodibenzo-p-dioxin increases the expression of genes in the human epidermal differentiation complex and accelerates epidermal barrier formation. Toxicol Sci. 2011;124(1):128-137. 13. Dietrich C. Antioxidant functions of the aryl hydrocarbon receptor. Stem Cells Int. 2016;2016:7943495. doi:10.1155/ 2016/7943495. 14. National Psoriasis Foundation. About psoriasis. https://www.psoriasis.org/about-psoriasis/. Accessed November 2020.
